Pub. Date : 2017 Aug 7
PMID : 28785074
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Low dose arsenite confers resistance to UV induced apoptosis via p53-MDM2 pathway in ketatinocytes. | arsenite | tumor protein p53 | Homo sapiens |
| 2 | We found that the cell apoptosis induced by UV exposure was significantly attenuated after exposure to low-dose arsenite, and knockdown of p53 could block UV-induced apoptosis indicating that this phenomenon depended on p53. | arsenite | tumor protein p53 | Homo sapiens |
| 3 | We found that the cell apoptosis induced by UV exposure was significantly attenuated after exposure to low-dose arsenite, and knockdown of p53 could block UV-induced apoptosis indicating that this phenomenon depended on p53. | arsenite | tumor protein p53 | Homo sapiens |
| 4 | In addition, treatment of PD98059 reversed low-dose arsenite-induced MDM2 expression, and the inhibition of ERK2 expression could significantly block MDM2 expression as a consequence, and p53 expression automatically was increased. | arsenite | tumor protein p53 | Homo sapiens |
| 5 | Taken together, our results demonstrated that low-dose arsenite-induced resistance to apoptosis through p53 mediated by MDM2 in keratinocytes. | arsenite | tumor protein p53 | Homo sapiens |