Title : Dexmedetomidine (DEX) protects against hepatic ischemia/reperfusion (I/R) injury by suppressing inflammation and oxidative stress in NLRC5 deficient mice.

Pub. Date : 2017 Nov 18

PMID : 28784305






1 Functional Relationships(s)
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1 After hepatic I/R injury, WT and NLRC5-/- mice pre-treated with DEX exhibited attenuated histological disruption, and reduced pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-1beta and inducible nitric oxide synthase (iNOS), which was associated with the inactivated NF-kappaB pathway. Dexmedetomidine interleukin 1 beta Mus musculus