Pub. Date : 2017 Aug
PMID : 28781650
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study investigated whether this urothelium-specific recombinant adenovirus (Ad5-UPII-E1A) enhanced mitomycin (MMC) and hydroxycamptothecin (HCPT) sensitization and drug-induced apoptosis in bladder cancer cells. | Mitomycin | uroplakin 2 | Homo sapiens |
| 2 | The present study investigated whether this urothelium-specific recombinant adenovirus (Ad5-UPII-E1A) enhanced mitomycin (MMC) and hydroxycamptothecin (HCPT) sensitization and drug-induced apoptosis in bladder cancer cells. | Mitomycin | uroplakin 2 | Homo sapiens |
| 3 | Treatment with MMC or HCPT enhanced Ad5-UPII-E1A-induced apoptosis in 5,637 cells, observed by transmission electron microscopy. | Mitomycin | uroplakin 2 | Homo sapiens |
| 4 | Western blot analysis revealed that MMC and HCPT enhanced the E1A expression of the Ad5-UPII-E1A vectorin a dose-dependent manner. | Mitomycin | uroplakin 2 | Homo sapiens |
| 5 | The present study demonstrated that Ad5-UPII-E1A combined with MMC or HCPT resulted in synergistic cytotoxicity in a process which involved the promotion of apoptosis in bladder cancer cell lines. | Mitomycin | uroplakin 2 | Homo sapiens |
| 6 | MMC and HCPT also promoted the oncolytic effect of Ad5-UPII-E1A. | Mitomycin | uroplakin 2 | Homo sapiens |