Pub. Date : 2017 Aug 4
PMID : 28779175
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. | Chlorides | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Mitochondrial ROS then induces the translocation of CLICs to the plasma membrane for the induction of chloride efflux to promote NEK7-NLRP3 interaction, inflammasome assembly, caspase-1 activation, and IL-1beta secretion. | Chlorides | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Thus, our results identify CLICs-dependent chloride efflux as an essential and proximal upstream event for NLRP3 activation.The NLRP3 inflammasome is key to the regulation of innate immunity against pathogens or stress, but the underlying signaling regulation is still unclear. | Chlorides | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Thus, our results identify CLICs-dependent chloride efflux as an essential and proximal upstream event for NLRP3 activation.The NLRP3 inflammasome is key to the regulation of innate immunity against pathogens or stress, but the underlying signaling regulation is still unclear. | Chlorides | NLR family pyrin domain containing 3 | Homo sapiens |