Title : CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation.

Pub. Date : 2017 Aug 4

PMID : 28779175






1 Functional Relationships(s)
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1 Mitochondrial ROS then induces the translocation of CLICs to the plasma membrane for the induction of chloride efflux to promote NEK7-NLRP3 interaction, inflammasome assembly, caspase-1 activation, and IL-1beta secretion. Reactive Oxygen Species interleukin 1 beta Homo sapiens