Pub. Date : 1986 Nov-Dec
PMID : 2877820
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, the increased rate of metabolism cannot be completely accounted for by the activity of the purified phenobarbital-inducible cytochrome P-450 isozyme 2, even in the presence of cytochrome b5. | Phenobarbital | cytochrome P450 2B4 | Oryctolagus cuniculus |
| 2 | The discovery of a second hepatic phenobarbital-inducible cytochrome P-450, isozyme 5, led us to undertake experiments to determine in hepatic and pulmonary preparations the portion of microsomal metabolism of methoxyflurane catalyzed by cytochrome P-450 isozymes 2 and 5. | Phenobarbital | cytochrome P450 2B4 | Oryctolagus cuniculus |
| 3 | In summary, we demonstrate that methoxyflurane O-demethylation in lung, phenobarbital-induced liver, and control liver microsomes is catalyzed by cytochrome P-450 isozymes 2 and 5. | Phenobarbital | cytochrome P450 2B4 | Oryctolagus cuniculus |