Title : Epigenetic silencing of LPP/miR-28 in multiple myeloma.

Pub. Date : 2018 Mar

PMID : 28775176






5 Functional Relationships(s)
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1 RESULTS: LPP/miR-28 was completely unmethylated in all healthy controls and 12 (80%) HMCLs, but partially methylated in three (20%) HMCLs. hmcls microRNA 28 Homo sapiens
2 Methylation of LPP/miR-28 correlated with low expression of miR-285p (p=0.012) and LPP (p=0.037) in HMCLs. hmcls microRNA 28 Homo sapiens
3 Moreover, a known miR-28-5p target, CCND1, was expressed at higher levels in HMCLs with LPP/miR-28 methylation than those without, consistent with a tumour suppressor role of miR-28-5p in myeloma. hmcls microRNA 28 Homo sapiens
4 Moreover, a known miR-28-5p target, CCND1, was expressed at higher levels in HMCLs with LPP/miR-28 methylation than those without, consistent with a tumour suppressor role of miR-28-5p in myeloma. hmcls microRNA 28 Homo sapiens
5 Moreover, a known miR-28-5p target, CCND1, was expressed at higher levels in HMCLs with LPP/miR-28 methylation than those without, consistent with a tumour suppressor role of miR-28-5p in myeloma. hmcls microRNA 28 Homo sapiens