Title : Atorvastatin increases Fads1, Fads2 and Elovl5 gene expression via the geranylgeranyl pyrophosphate-dependent Rho kinase pathway in 3T3-L1 cells.

Pub. Date : 2017 Oct

PMID : 28765914






3 Functional Relationships(s)
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1 Atorvastatin increases Fads1, Fads2 and Elovl5 gene expression via the geranylgeranyl pyrophosphate-dependent Rho kinase pathway in 3T3-L1 cells. Atorvastatin fatty acid desaturase 2 Mus musculus
2 Treatment with atorvastatin decreased cell viability and increased the mRNA expression levels of Fads1, Fads2 and ELOVL fatty acid elongase 5 (Elovl5) in a dose-dependent manner. Atorvastatin fatty acid desaturase 2 Mus musculus
3 The Rho-associated protein kinase inhibitor Y-27632 inhibited the mevalonate- and GGPP-mediated reversal of atorvastatin-induced upregulation of Fads1, Fads2 and Elovl5. Atorvastatin fatty acid desaturase 2 Mus musculus