Pub. Date : 2017 Sep 14
PMID : 28764908
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cystathionine-beta-synthase(CBS) is the main enzymes of synthesis of H2S in the brain. | Hydrogen Sulfide | cystathionine beta synthase | Rattus norvegicus |
| 2 | Cystathionine-beta-synthase(CBS) is the main enzymes of synthesis of H2S in the brain. | Hydrogen Sulfide | cystathionine beta synthase | Rattus norvegicus |
| 3 | In the injured SN of 6-OHDA-induced PD rats, the CBS expression and the endogenous H2S level markedly decreased, while administration of lentivirus-mediated CBS overexpression increased the CBS expression and the endogenous H2S production.CBS overexpression dramatically reversed apomorphine-induced rotation of the 6-OHDA model rats, decreased the number of TUNEL-positive neurons and the loss of the nigral DA neurons,specifically inhibited 6-OHDA-induced oxidase stress injury, and down-regulated the expression of alpha-synuclein(alpha-SYN) in the injured SN. | Hydrogen Sulfide | cystathionine beta synthase | Rattus norvegicus |
| 4 | In the injured SN of 6-OHDA-induced PD rats, the CBS expression and the endogenous H2S level markedly decreased, while administration of lentivirus-mediated CBS overexpression increased the CBS expression and the endogenous H2S production.CBS overexpression dramatically reversed apomorphine-induced rotation of the 6-OHDA model rats, decreased the number of TUNEL-positive neurons and the loss of the nigral DA neurons,specifically inhibited 6-OHDA-induced oxidase stress injury, and down-regulated the expression of alpha-synuclein(alpha-SYN) in the injured SN. | Hydrogen Sulfide | cystathionine beta synthase | Rattus norvegicus |
| 5 | In the injured SN of 6-OHDA-induced PD rats, the CBS expression and the endogenous H2S level markedly decreased, while administration of lentivirus-mediated CBS overexpression increased the CBS expression and the endogenous H2S production.CBS overexpression dramatically reversed apomorphine-induced rotation of the 6-OHDA model rats, decreased the number of TUNEL-positive neurons and the loss of the nigral DA neurons,specifically inhibited 6-OHDA-induced oxidase stress injury, and down-regulated the expression of alpha-synuclein(alpha-SYN) in the injured SN. | Hydrogen Sulfide | cystathionine beta synthase | Rattus norvegicus |
| 6 | In the injured SN of 6-OHDA-induced PD rats, the CBS expression and the endogenous H2S level markedly decreased, while administration of lentivirus-mediated CBS overexpression increased the CBS expression and the endogenous H2S production.CBS overexpression dramatically reversed apomorphine-induced rotation of the 6-OHDA model rats, decreased the number of TUNEL-positive neurons and the loss of the nigral DA neurons,specifically inhibited 6-OHDA-induced oxidase stress injury, and down-regulated the expression of alpha-synuclein(alpha-SYN) in the injured SN. | Hydrogen Sulfide | cystathionine beta synthase | Rattus norvegicus |
| 7 | In the injured SN of 6-OHDA-induced PD rats, the CBS expression and the endogenous H2S level markedly decreased, while administration of lentivirus-mediated CBS overexpression increased the CBS expression and the endogenous H2S production.CBS overexpression dramatically reversed apomorphine-induced rotation of the 6-OHDA model rats, decreased the number of TUNEL-positive neurons and the loss of the nigral DA neurons,specifically inhibited 6-OHDA-induced oxidase stress injury, and down-regulated the expression of alpha-synuclein(alpha-SYN) in the injured SN. | Hydrogen Sulfide | cystathionine beta synthase | Rattus norvegicus |
| 8 | In the injured SN of 6-OHDA-induced PD rats, the CBS expression and the endogenous H2S level markedly decreased, while administration of lentivirus-mediated CBS overexpression increased the CBS expression and the endogenous H2S production.CBS overexpression dramatically reversed apomorphine-induced rotation of the 6-OHDA model rats, decreased the number of TUNEL-positive neurons and the loss of the nigral DA neurons,specifically inhibited 6-OHDA-induced oxidase stress injury, and down-regulated the expression of alpha-synuclein(alpha-SYN) in the injured SN. | Hydrogen Sulfide | cystathionine beta synthase | Rattus norvegicus |