Title : Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis.

Pub. Date : 2017 Jul 31

PMID : 28761045






1 Functional Relationships(s)
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1 Here, we report that inhibiting NLRP3 with the selective inhibitor MCC950, blocked release of IL-1beta and the related cytokine IL-1alpha from primary human monocytes in response to S. typhimurium. N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide interleukin 1 beta Homo sapiens