Title : Plasma concentrations and pharmacokinetics of midazolam during anaesthesia.

Pub. Date : 1986 Aug

PMID : 2876073






1 Functional Relationships(s)
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1 Minimum plasma concentrations of midazolam measured just before each injection were 258.8 +/- 108.4 ng ml-1 for the first protocol and 353.1 +/- 55.2 ng ml-1 for the second protocol; maximum midazolam concentrations, measured 5 min after the last administration, were 1103.1 +/- 237.9 ng ml-1 and 743.0 +/- 103.2 ng ml-1, respectively, suggesting that a continuous infusion of midazolam after a loading dose should be better than repeated injections at keeping the concentration close to the sedative level of 400 ng ml-1. Midazolam interleukin 17F Homo sapiens