Title : Impact of Aldosterone Synthase Inhibitor FAD286 on Steroid Hormone Profile in Human Adrenocortical Cells.

Pub. Date : 2017 Sep

PMID : 28759940






2 Functional Relationships(s)
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1 Higher concentrations of FAD286 did not further reduce aldosterone concentrations, but showed a parallel reduction in corticosterone, cortisol and cortisone levels, reflecting additional inhibition of steroid-11beta-hydroxylase (CYP11B1). Fadrozole cytochrome P450 family 11 subfamily B member 1 Homo sapiens
2 Higher concentrations of FAD286 did not further reduce aldosterone concentrations, but showed a parallel reduction in corticosterone, cortisol and cortisone levels, reflecting additional inhibition of steroid-11beta-hydroxylase (CYP11B1). Fadrozole cytochrome P450 family 11 subfamily B member 1 Homo sapiens