Title : Sulfonyl phosphonic 1,4-dithia-7-azaspiro[4,4]nonane derivatives as matrix metalloproteinase inhibitors: Synthesis, a docking study, and biological evaluation.

Pub. Date : 2017

PMID : 28757512






1 Functional Relationships(s)
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Protein Name
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1 Compound 6d displayed the greatest inhibitory activity in an enzymatic assay and a cell-based assay, which means that this compound is a good candidate for further development of phosphonate-based MMP inhibitors. Organophosphonates matrix metallopeptidase 2 Homo sapiens