Pub. Date : 2017 Nov 15
PMID : 28756656
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we report a strategy for CNS-selective distribution of the carboxylic acid containing thyromimetic sobetirome using prodrugs targeted to fatty-acid amide hydrolase (FAAH), which is expressed in the brain. | GC 1 compound | fatty acid amide hydrolase | Mus musculus |
| 2 | Two amide prodrugs of sobetirome were shown to be efficient substrates of FAAH with Vmax/KM values comparable to the natural endocannabinoid FAAH substrate anandamide. | GC 1 compound | fatty acid amide hydrolase | Mus musculus |
| 3 | Two amide prodrugs of sobetirome were shown to be efficient substrates of FAAH with Vmax/KM values comparable to the natural endocannabinoid FAAH substrate anandamide. | GC 1 compound | fatty acid amide hydrolase | Mus musculus |
| 4 | The increased delivery of sobetirome to the brain from the prodrug was diminished by both pharmacological inhibition and genetic deletion of FAAH in vivo. | GC 1 compound | fatty acid amide hydrolase | Mus musculus |