Pub. Date : 2017
PMID : 28750403
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ablation of the Cl-/HCO3- Exchanger Pendrin Enhances Hydrochlorothiazide-Induced Diuresis. | Hydrochlorothiazide | solute carrier family 26, member 4 | Mus musculus |
| 2 | We hypothesized that deletion of pendrin leaves NCC as the major salt absorbing transporter in the distal nephron and therefore enhances salt excretion by hydrochlorothiazide (HCTZ). | Hydrochlorothiazide | solute carrier family 26, member 4 | Mus musculus |
| 3 | We hypothesized that deletion of pendrin leaves NCC as the major salt absorbing transporter in the distal nephron and therefore enhances salt excretion by hydrochlorothiazide (HCTZ). | Hydrochlorothiazide | solute carrier family 26, member 4 | Mus musculus |
| 4 | Urine output and water intake increased significantly only in pendrin KO mice in response to HCTZ, but not in WT or NCC KO mice. | Hydrochlorothiazide | solute carrier family 26, member 4 | Mus musculus |
| 5 | Sodium and chloride excretion increased in HCTZ-treated pendrin KO mice, but they remained unchanged in WT or NCC KO mice. | Hydrochlorothiazide | solute carrier family 26, member 4 | Mus musculus |
| 6 | Pendrin KO mice treated with HCTZ developed volume depletion, as determined by increased expression of renin mRNA and protein. | Hydrochlorothiazide | solute carrier family 26, member 4 | Mus musculus |
| 7 | The expression of ENaC and pendrin increased in HCTZ-treated WT mice. | Hydrochlorothiazide | solute carrier family 26, member 4 | Mus musculus |
| 8 | CONCLUSION: The ablation of the Cl-/HCO3- exchanger Pendrin enhances the magnitude of salt wasting by HCTZ. | Hydrochlorothiazide | solute carrier family 26, member 4 | Mus musculus |