Title : Kinase inhibitors of HER2/AKT pathway induce ERK phosphorylation via a FOXO-dependent feedback loop.

Pub. Date : 2017

PMID : 28744398






2 Functional Relationships(s)
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1 Notably, the Lapatinib treatment-induced phosphorylation of ERK was dependent on FOXO transcription factors, which are also activated by Lapatinib-mediated suppression of AKT. Lapatinib AKT serine/threonine kinase 1 Homo sapiens
2 Notably, the Lapatinib treatment-induced phosphorylation of ERK was dependent on FOXO transcription factors, which are also activated by Lapatinib-mediated suppression of AKT. Lapatinib AKT serine/threonine kinase 1 Homo sapiens