Pub. Date : 2017
PMID : 28740545
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | E-selectin-targeted Sialic Acid-PEG-dexamethasone Micelles for Enhanced Anti-Inflammatory Efficacy for Acute Kidney Injury. | N-Acetylneuraminic Acid | selectin E | Homo sapiens |
| 2 | Sialic acid (SA) is main component of Sialyl Lewisx antigen on the mammalian cell surface, which participates in E-selectin binding. | N-Acetylneuraminic Acid | selectin E | Homo sapiens |
| 3 | Sialic acid (SA) is main component of Sialyl Lewisx antigen on the mammalian cell surface, which participates in E-selectin binding. | N-Acetylneuraminic Acid | selectin E | Homo sapiens |
| 4 | Therefore, dexamethasone(DXM)-loaded E-selectin-targeting sialic acid-polyethylene glycol-dexamethasone (SA-PEG-DXM/DXM) conjugate micelles are designed for ameliorating AKI. | N-Acetylneuraminic Acid | selectin E | Homo sapiens |
| 5 | Much more SA-PEG-DXM micelles can be internalized by lipopolysaccharide (LPS)-activated human umbilical vein endothelial cells (HUVECs) in comparison to PEG-DXM micelles due to specific interaction between SA and E-selectin expressed on HUVECs, and consequently more SA-PEG-DXM micelles are accumulated in the kidney of AKI murine model. | N-Acetylneuraminic Acid | selectin E | Homo sapiens |