Title : Control of the NADPH supply for oxidative stress handling in cancer cells.

Pub. Date : 2017 Nov

PMID : 28739529






2 Functional Relationships(s)
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1 In the present work, it was determined in non-cancer and cancer cells the protein contents and kinetomics of (i) the cytosolic enzymes responsible for the NADPH production (i.e., Glc6PDH, 6PGDH, ME, IDH-1); and (ii) the two main enzymes responsible for NADPH/NADP+ and GSH/GSSG recycling (GR, GPx-1) associated to oxidative stress management. NADP isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 In the present work, it was determined in non-cancer and cancer cells the protein contents and kinetomics of (i) the cytosolic enzymes responsible for the NADPH production (i.e., Glc6PDH, 6PGDH, ME, IDH-1); and (ii) the two main enzymes responsible for NADPH/NADP+ and GSH/GSSG recycling (GR, GPx-1) associated to oxidative stress management. NADP isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens