Title : Clinical significance of miR-138 in patients with malignant melanoma through targeting of PDK1 in the PI3K/AKT autophagy signaling pathway.

Pub. Date : 2017 Sep

PMID : 28731179






1 Functional Relationships(s)
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1 LY294002, an inhibitor of PI3K, suppressed PI3K/AKT/mTOR signaling, induced apoptosis, inhibited cell proliferation, increased caspase-3 and Bax protein expression, and decreased PDK1 protein expression in A2058 cells following miR-138 overexpression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one BCL2 associated X, apoptosis regulator Homo sapiens