Pub. Date : 2017 Sep 15
PMID : 28729418
6 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells. | Mevalonic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens | ||
| 2 | Here, we link metabolic dysregulation in patient-derived brain tumor-initiating cells (BTIC) to a nexus between MYC and mevalonate signaling, which can be inhibited by statin or 6-fluoromevalonate treatment. | Mevalonic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens | ||
| 3 | BTICs preferentially express mevalonate pathway enzymes, which we find regulated by novel MYC-binding sites, validating an additional transcriptional activation role of MYC in cancer metabolism. | Mevalonic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens | ||
| 4 | BTICs preferentially express mevalonate pathway enzymes, which we find regulated by novel MYC-binding sites, validating an additional transcriptional activation role of MYC in cancer metabolism. | Mevalonic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens | ||
| 5 | In turn, mevalonate created a positive feed-forward loop to activate MYC signaling via induction of miR-33b. | Mevalonic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens | ||
| 6 | Collectively, our results argue that MYC mediates its oncogenic effects in part by altering mevalonate metabolism in glioma cells, suggesting a therapeutic strategy in this setting. | Mevalonic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens | ||