Title : Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin.

Pub. Date : 2018 Jul

PMID : 28727687






2 Functional Relationships(s)
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1 Administering Dnmt1 inhibitor to control neonates resulted in FAE-like deficits in fear memory and hippocampal allele-specific expression of Igf2, which were reversed by metformin. Metformin DNA methyltransferase 1 Rattus norvegicus
2 We propose that neonatal administration of T4 and metformin post FAE affect memory via elevating Dnmt1 and consequently normalizing hippocampal Dio3 and Igf2 expressions in the adult offspring. Metformin DNA methyltransferase 1 Rattus norvegicus