Title : Relative potencies of various beta-adrenoceptor antagonists (BAA) at the level of the human myocardial beta-adrenoceptor-adenylate cyclase (AC) complex. Is intrinsic sympathomimetic activity (ISA) due to AC activation?

Pub. Date : 1986 Apr

PMID : 2872714






1 Functional Relationships(s)
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1 In comparison, norepinephrine stimulated AC activity to the same level as isoproterenol (three to four times basal activity) and the beta 2-selective agonist terbutaline caused some 50% of maximal AC stimulation. Terbutaline potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens