Title : In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication.

Pub. Date : 2018 Jan

PMID : 28722512






3 Functional Relationships(s)
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Protein Name
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1 In silico the molecular interactions between AChE and oximes were examined and binding energies were assessed. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
2 In vitro the intrinsic ability of the oximes to inhibit AChE (IC50) and their reactivation potency (R50) when used in paraoxon inhibited human RBC-AChE was determined. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
3 In vitro the intrinsic ability of the oximes to inhibit AChE (IC50) and their reactivation potency (R50) when used in paraoxon inhibited human RBC-AChE was determined. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens