Title : Ibrutinib, a Bruton's tyrosine kinase inhibitor, exhibits antitumoral activity and induces autophagy in glioblastoma.

Pub. Date : 2017 Jul 17

PMID : 28716053






3 Functional Relationships(s)
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1 Overexpression of the active Akt protein decreased ibrutinib-induced autophagy, while inhibiting Akt by LY294002 treatment enhanced ibrutinib-induced autophagy. ibrutinib AKT serine/threonine kinase 1 Homo sapiens
2 Overexpression of the active Akt protein decreased ibrutinib-induced autophagy, while inhibiting Akt by LY294002 treatment enhanced ibrutinib-induced autophagy. ibrutinib AKT serine/threonine kinase 1 Homo sapiens
3 CONCLUSIONS: Our results indicate that ibrutinib exerts a profound antitumor effect and induces autophagy through Akt/mTOR signaling pathway in GBM cells. ibrutinib AKT serine/threonine kinase 1 Homo sapiens