Pub. Date : 2017 Jul 17
PMID : 28716053
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Overexpression of the active Akt protein decreased ibrutinib-induced autophagy, while inhibiting Akt by LY294002 treatment enhanced ibrutinib-induced autophagy. | ibrutinib | AKT serine/threonine kinase 1 | Homo sapiens |
2 | Overexpression of the active Akt protein decreased ibrutinib-induced autophagy, while inhibiting Akt by LY294002 treatment enhanced ibrutinib-induced autophagy. | ibrutinib | AKT serine/threonine kinase 1 | Homo sapiens |
3 | CONCLUSIONS: Our results indicate that ibrutinib exerts a profound antitumor effect and induces autophagy through Akt/mTOR signaling pathway in GBM cells. | ibrutinib | AKT serine/threonine kinase 1 | Homo sapiens |