Pub. Date : 2017 Oct
PMID : 28715732
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we found that HSP90 was cleaved to a 55kDa protein after treatment with proteasome inhibitors including MG132 in leukemia cells but was not cleaved in other tissue-derived cells. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | HSP90 has two major isoforms (HSP90alpha and HSP90beta), and both were cleaved by MG132 treatment. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | HSP90 has two major isoforms (HSP90alpha and HSP90beta), and both were cleaved by MG132 treatment. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 4 | MG132 treatment also induced a decrease in HSP90 client proteins. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 5 | MG132 treatment generated ROS, and the cleavage of HSP90 was blocked by a ROS scavenger, N-acetylcysteine (NAC). | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 6 | Based on an inhibitor study, the cleavage of HSP90 induced by MG132 was dependent on caspase 10 activation. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 7 | Taken all together, our results suggest that the cleavage of HSP90 by MG132 treatment is mediated by ROS generation and caspase 10 activation. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | heat shock protein 90 alpha family class A member 1 | Homo sapiens |