Pub. Date : 2017 Aug
PMID : 28714512
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of STAT3 signaling pathway by ursolic acid suppresses growth of hepatocellular carcinoma. | ursolic acid | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | However, whether UA could inhibit STAT3 phosphorylation in hepatocellular carcinoma has not been reported. | ursolic acid | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | The inhibitory effects of UA on STAT3 phosphorylation, along with cell viability, migration, colony formation in vitro, as well as tumor growth in vivo were examined in human liver cancer cell lines. | ursolic acid | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | Our data showed that UA inhibited the P-STAT3 induced by interleukin-6 (IL-6) in Hep3B liver cancer cells which express very low basal level of P-STAT3. | ursolic acid | signal transducer and activator of transcription 3 | Homo sapiens |
| 5 | Our data showed that UA inhibited the P-STAT3 induced by interleukin-6 (IL-6) in Hep3B liver cancer cells which express very low basal level of P-STAT3. | ursolic acid | signal transducer and activator of transcription 3 | Homo sapiens |
| 6 | The constitutive STAT3 phosphorylation was also inhibited by UA in HEPG2, 7721 and Huh7 human liver cancer cell lines. | ursolic acid | signal transducer and activator of transcription 3 | Homo sapiens |
| 7 | UA decreased the expression of downstream target genes of STAT3, such as Bcl-2, Bcl-xl and survivin in general, with difference in these cell lines. | ursolic acid | signal transducer and activator of transcription 3 | Homo sapiens |
| 8 | UA, which exists widely in fruits and herbs, could inhibit STAT3 activation and the growth of human liver cancer cells in vitro and in vivo. | ursolic acid | signal transducer and activator of transcription 3 | Homo sapiens |