Title : Etoposide and doxorubicin enhance the sensitivity of triple negative breast cancers through modulation of TRAIL-DR5 axis.

Pub. Date : 2017 Oct

PMID : 28702823






4 Functional Relationships(s)
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1 Etoposide and doxorubicin enhance the sensitivity of triple negative breast cancers through modulation of TRAIL-DR5 axis. Doxorubicin TNF superfamily member 10 Homo sapiens
2 In the TRAIL pre-treated cells, ET and DOX induced higher apoptosis, indicating their synergistic effect with TRAIL. Doxorubicin TNF superfamily member 10 Homo sapiens
3 In the TRAIL pre-treated cells, ET and DOX induced higher apoptosis, indicating their synergistic effect with TRAIL. Doxorubicin TNF superfamily member 10 Homo sapiens
4 The binding energy for TRAIL-DR5 complexation in the ternary complexes containing ET (-111.08 kcal/mol) and DOX (-76.35 kcal/mol) were higher than reported binding energy of binary complex (-53.70 kcal/mol). Doxorubicin TNF superfamily member 10 Homo sapiens