Title : Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.

Pub. Date : 2017 Aug 25

PMID : 28696262






1 Functional Relationships(s)
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1 Examination of available sequence data suggests that Arg-135 may have originated for l-THA-like beta-elimination function in earlier evolutionary variants, and examination of available structural data suggests that a Ser84-H2O-Lys114 hydrogen-bonding network in human serine racemase lowers the pKa of the Ser84re-face base. ser84re serine racemase Homo sapiens