Title : Flavoenzyme-mediated reduction reactions and antitumor activity of nitrogen-containing tetracyclic ortho-quinone compounds and their nitrated derivatives.

Pub. Date : 2017

PMID : 28694766






1 Functional Relationships(s)
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1 The compounds were highly reactive substrates of single- and two-electron (hydride) - transferring P-450R (CPR; EC 1.6.2.4) and NQO-1 (DTD; EC 1.6.99.2), respectively, concomitantly producing reactive oxygen species. Reactive Oxygen Species NAD(P)H quinone dehydrogenase 1 Homo sapiens