Title : Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells.

Pub. Date : 2017 Aug

PMID : 28685208






7 Functional Relationships(s)
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1 Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells. Iron monoamine oxidase B Homo sapiens
2 However, the association of iron with MAO-B activity was poorly understood. Iron monoamine oxidase B Homo sapiens
3 Here we took advantage of highly sensitive and specific fluorescence probes to examine the change in MAO-B activity in human dopaminergic neuroblastoma (SH-SY5Y) cells upon iron exposure. Iron monoamine oxidase B Homo sapiens
4 In addition, iron-induced increase in MAO-B probe fluorescence could be prevented by pargyline and other newly developed MAO-B inhibitors, suggesting that it was MAO-B activity-dependent. Iron monoamine oxidase B Homo sapiens
5 In addition, iron-induced increase in MAO-B probe fluorescence could be prevented by pargyline and other newly developed MAO-B inhibitors, suggesting that it was MAO-B activity-dependent. Iron monoamine oxidase B Homo sapiens
6 In addition, iron-induced increase in MAO-B probe fluorescence could be prevented by pargyline and other newly developed MAO-B inhibitors, suggesting that it was MAO-B activity-dependent. Iron monoamine oxidase B Homo sapiens
7 These findings may suggest MAO-B is an important sensor in iron-stressed neuronal cells. Iron monoamine oxidase B Homo sapiens