Pub. Date : 2017 Dec
PMID : 28681937
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Maternal nicotine exposure leads to decreased cardiac protein disulfide isomerase and impaired mitochondrial function in male rat offspring. | Nicotine | prolyl 4-hydroxylase subunit beta | Rattus norvegicus |
| 2 | Recently, our laboratory demonstrated that nicotine impairs placental protein disulfide isomerase (PDI) triggering an increase in endoplasmic reticulum stress, leading us to hypothesize that this may also occur in the heart. | Nicotine | prolyl 4-hydroxylase subunit beta | Rattus norvegicus |
| 3 | Recently, our laboratory demonstrated that nicotine impairs placental protein disulfide isomerase (PDI) triggering an increase in endoplasmic reticulum stress, leading us to hypothesize that this may also occur in the heart. | Nicotine | prolyl 4-hydroxylase subunit beta | Rattus norvegicus |
| 4 | At 3 months of age, nicotine-exposed offspring had 45% decreased PDI levels in the absence of endoplasmic reticulum stress. | Nicotine | prolyl 4-hydroxylase subunit beta | Rattus norvegicus |
| 5 | Collectively, this study suggests that perinatal nicotine exposure decreases PDI, which can promote oxidative damage and mitochondrial damage, associated with a premature decline in cardiac function. | Nicotine | prolyl 4-hydroxylase subunit beta | Rattus norvegicus |