Title : Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of α-endosulfan and dioxin in HepaRG human cells.

Pub. Date : 2017 Dec

PMID : 28673560






2 Functional Relationships(s)
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1 Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of alpha-endosulfan and dioxin in HepaRG human cells. Endosulfan alcohol dehydrogenase 4 (class II), pi polypeptide Homo sapiens
2 We show that the combination of the two pollutants (25nM TCDD and 10muM alpha-endosulfan) led to marked decreases in the amounts of both the mRNA (up to 90%) and protein (up to 60%) of ADH4 and CYP2E1. Endosulfan alcohol dehydrogenase 4 (class II), pi polypeptide Homo sapiens