Pub. Date : 2017 Sep 2
PMID : 28669722
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tacrolimus induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-429 and its target of RhoE. | Tacrolimus | microRNA 429 | Rattus norvegicus |
| 2 | The expression of miR-429 in fibroblasts treated with FK506 was determined by RT-qPCR. | Tacrolimus | microRNA 429 | Rattus norvegicus |
| 3 | The results revealed FK506 induces fibroblast apoptosis and significantly downregulates miR-429 expression in fibroblasts. | Tacrolimus | microRNA 429 | Rattus norvegicus |
| 4 | The rat model demonstrated miR-429 inhibition promotes fibroblast apoptosis and epidural fibrosis, which is consistent with the results of FK506 treatment. | Tacrolimus | microRNA 429 | Rattus norvegicus |
| 5 | Our study demonstrates that FK506 induces fibroblast apoptosis and reduces epidural fibrosis by regulating miR-429 expression and its target of RhoE. | Tacrolimus | microRNA 429 | Rattus norvegicus |