Pub. Date : 2018 Apr
PMID : 28661933
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | At 20 h after CLP, PYR-41 treatment significantly decreased serum levels of proinflammatory cytokines (TNF-alpha, interleukin [IL]-1beta, and IL-6) and organ injury markers (aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase). | 4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester | interleukin 1 beta | Mus musculus |
| 2 | PYR-41 inhibited the expression of cytokines (IL-1beta and IL-6), chemokines (keratinocyte-derived chemokine and macrophage inflammatory protein 2), and inflammatory mediators (cyclooxygenase-2 and inducible nitric oxide synthase) in the lungs of septic mice. | 4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester | interleukin 1 beta | Mus musculus |