Title : Increased hepatic ABCA1 transporter is associated with hypercholesterolemia in a cholestatic rat model and primary biliary cholangitis patients.

Pub. Date : 2017 Dec

PMID : 28660384






7 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Hepatic ATP-binding cassette A1 (ABCA1) transporter is the modulator of intrahepatic cholesterol levels via the efflux of cholesterol into plasma. Cholesterol ATP binding cassette subfamily A member 1 Rattus norvegicus
2 Hepatic ATP-binding cassette A1 (ABCA1) transporter is the modulator of intrahepatic cholesterol levels via the efflux of cholesterol into plasma. Cholesterol ATP binding cassette subfamily A member 1 Rattus norvegicus
3 Hepatic ATP-binding cassette A1 (ABCA1) transporter is the modulator of intrahepatic cholesterol levels via the efflux of cholesterol into plasma. Cholesterol ATP binding cassette subfamily A member 1 Rattus norvegicus
4 Hepatic ATP-binding cassette A1 (ABCA1) transporter is the modulator of intrahepatic cholesterol levels via the efflux of cholesterol into plasma. Cholesterol ATP binding cassette subfamily A member 1 Rattus norvegicus
5 A cholesterol efflux study was conducted with Abca1 knock down using siRNA in WIF9 cells. Cholesterol ATP binding cassette subfamily A member 1 Rattus norvegicus
6 Cholesterol levels in the ABCA1 siRNA cells in the medium were significantly decreased compared with those in controls (P < 0.05). Cholesterol ATP binding cassette subfamily A member 1 Rattus norvegicus
7 Upregulated hepatic ABCA1 may lead to efflux of cholesterol into plasma, thus explaining the mechanism of cholestasis leading to hypercholesterolemia. Cholesterol ATP binding cassette subfamily A member 1 Rattus norvegicus