Pub. Date : 2017 Jun 27
PMID : 28658616
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we demonstrate that mTORC1 itself is suppressed by drugs that reduce intracellular purine nucleotide pools. | purine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Cellular treatment with AG2037, an inhibitor of the purine biosynthetic enzyme GARFT, profoundly inhibits mTORC1 activity via a reduction in the level of GTP-bound Rheb, an obligate upstream activator of mTORC1, because of a reduction in intracellular guanine nucleotides. | purine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | These results indicate that alterations in purine nucleotide availability affect mTORC1 activity and suggest that inhibition of mTORC1 contributes to the therapeutic effects of purine biosynthesis inhibitors. | purine | CREB regulated transcription coactivator 1 | Mus musculus |
| 4 | These results indicate that alterations in purine nucleotide availability affect mTORC1 activity and suggest that inhibition of mTORC1 contributes to the therapeutic effects of purine biosynthesis inhibitors. | purine | CREB regulated transcription coactivator 1 | Mus musculus |