Title : In vitro evaluation of the inhibition and induction potential of olaparib, a potent poly(ADP-ribose) polymerase inhibitor, on cytochrome P450.

Pub. Date : 2018 Jun

PMID : 28657402






2 Functional Relationships(s)
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1 Assessment of the CYP induction potential of olaparib (0.061-44 muM) showed minor concentration-related increases in CYP1A2 and more marked increases in CYP2B6 and CYP3A4 mRNA, compared with positive control activity; however, no significant change in CYP3A4/5 enzyme activity was observed. olaparib cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 It is recommended that olaparib is given with caution with narrow therapeutic range or sensitive CYP3A substrates, and that prescribers are aware that olaparib may reduce exposure to substrates of CYP2B6. olaparib cytochrome P450 family 2 subfamily B member 6 Homo sapiens