Pub. Date : 2017 Aug
PMID : 28654865
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Of the two phosphatidylcholine-specific PLD enzymes, only PLD1, but not PLD2, mRNA was down-regulated by doxorubicin treatment. | Doxorubicin | phospholipase D1 | Homo sapiens |
| 2 | PLD1 and ChKalpha protein levels decreased following doxorubicin treatment in a concentration dependent manner. | Doxorubicin | phospholipase D1 | Homo sapiens |
| 3 | Treatment with the PLD1 specific inhibitor VU0155069 sensitized MCF7 and MDA-MB-231 breast cancer cells to doxorubicin-induced cytotoxicity. | Doxorubicin | phospholipase D1 | Homo sapiens |
| 4 | Doxorubicin induced GPC increase and PC decrease are caused by reductions in PLD1, GDPD6, and ChKalpha mRNA and protein expression. | Doxorubicin | phospholipase D1 | Homo sapiens |