Title : Development of selective inhibitors of transglutaminase. Phenylthiourea derivatives.

Pub. Date : 1985 Nov 25

PMID : 2865262






1 Functional Relationships(s)
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1 The Ki value (4.9 X 10(-5) M) of 1-(5-aminopentyl)-3-phenylthiourea (PPTU) (n = 5) for the inhibition of guinea pig transglutaminase-catalyzed amine incorporation into the B chain of oxidized insulin is in close agreement to its Km(app) value (7.1 X 10(-5) M) obtained using 14C-labeled PPTU. Carbon-14 protein-glutamine gamma-glutamyltransferase 2 Cavia porcellus