Title : A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.

Pub. Date : 2017 Oct 26

PMID : 28650469






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT/GSK3beta signaling axis at cilia in SHH-dependent medulloblastoma that is regulated by INPP5E to maintain tumor cell cilia, promote SHH signaling and thereby medulloblastoma progression. phosphatidylinositol 3,4,5-triphosphate thymoma viral proto-oncogene 1 Mus musculus