Pub. Date : 1985 Nov
PMID : 2864237
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Concomitant treatment of testicular cells with nicotinic cholinergic agonists (lobeline, nicotine, and dimethylphenylpiperazinium iodide) inhibited hCG-stimulated androgen biosynthesis in a dose-dependent fashion, with IC50 values of 3 X 10(-5), 1.7 X 10(-4), and greater than 10(-3) M, respectively. | Lobeline | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 2 | Lobeline (10-4) M) decreased hCG-stimulated testosterone production (50-75%) throughout the 2-day culture period; however, this inhibition was reversible upon removal of the drug. | Lobeline | hypertrichosis 2 (generalised, congenital) | Homo sapiens |
| 3 | Lobeline also inhibited hCG-stimulated cAMP accumulation as well as testosterone production induced by cholera toxin (65% inhibition), forskolin (50% inhibition), or (Bu)2cAMP (70% inhibition). | Lobeline | hypertrichosis 2 (generalised, congenital) | Homo sapiens |