Pub. Date : 2017 Aug 15
PMID : 28642033
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice. | benzotropolone | autophagy related 4B, cysteine peptidase | Mus musculus |
| 2 | We recently identified a benzotropolone derivative that significantly inhibited the essential autophagy protein ATG4B. | benzotropolone | autophagy related 4B, cysteine peptidase | Mus musculus |
| 3 | Therefore, we synthesized and tested additional benzotropolone compounds to identify a promising ATG4B inhibitor that impairs autophagy both in vitro and in vivo. | benzotropolone | autophagy related 4B, cysteine peptidase | Mus musculus |
| 4 | A compound library containing 27 molecules with a benzotropolone backbone was synthesized and screened for inhibition of recombinant ATG4B. | benzotropolone | autophagy related 4B, cysteine peptidase | Mus musculus |
| 5 | Depending on the benzotropolone compound, inhibition of recombinant ATG4B ranged from 3 to 82%. | benzotropolone | autophagy related 4B, cysteine peptidase | Mus musculus |