Pub. Date : 2018 Jan
PMID : 28639178
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin was encapsulated in DOTAP-based cationic liposomes and then complexed with STAT3 siRNA. | Curcumin | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | The cell viability studies in B16F10 mouse melanoma cells have shown that the co-delivery of curcumin and STAT3 siRNA significantly (p < 0.05) inhibited the cancer cell growth compared with either liposomal curcumin or STAT3 siRNA alone. | Curcumin | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | Co-administration of the curcumin and STAT3 siRNA using liposomes significantly (p < 0.05) inhibited the tumor progression as measured by tumor volume and tumor weight compared with either liposomal curcumin or STAT3 siRNA alone. | Curcumin | signal transducer and activator of transcription 3 | Mus musculus |
| 4 | Co-administration of the curcumin and STAT3 siRNA using liposomes significantly (p < 0.05) inhibited the tumor progression as measured by tumor volume and tumor weight compared with either liposomal curcumin or STAT3 siRNA alone. | Curcumin | signal transducer and activator of transcription 3 | Mus musculus |
| 5 | Furthermore, the iontophoretic administration of curcumin-loaded liposome-siRNA complex showed similar effectiveness in inhibiting tumor progression and STAT3 protein suppression compared with intratumoral administration. | Curcumin | signal transducer and activator of transcription 3 | Mus musculus |