Pub. Date : 1985 Jul-Aug
PMID : 2863109
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evidence for the metabolism of N-nitrosodimethylamine and carbon tetrachloride by a common isozyme of cytochrome P-450. | Carbon Tetrachloride | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 2 | Carbon tetrachloride administration to rats produced a selective loss of hepatic cytochrome P-450-dependent catalytic activities. | Carbon Tetrachloride | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 3 | Of the cytochrome P-450-dependent catalytic activities tested, the metabolism of carbon tetrachloride to phosgene and the low Km N-nitrosodimethylamine demethylase were the most sensitive to destruction by carbon tetrachloride. | Carbon Tetrachloride | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 4 | Of the cytochrome P-450-dependent catalytic activities tested, the metabolism of carbon tetrachloride to phosgene and the low Km N-nitrosodimethylamine demethylase were the most sensitive to destruction by carbon tetrachloride. | Carbon Tetrachloride | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 5 | The similarities between both the loss and the induction of the low Km N-nitrosodimethylamine demethylase and the metabolism of carbon tetrachloride to phosgene suggest that these catalytic activities represent a common isozyme of cytochrome P-450. | Carbon Tetrachloride | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 6 | Analysis of cytochromes P-450 by HPLC provided evidence for an isozyme of cytochrome P-450 inducible by pyrazole and destroyed by carbon tetrachloride. | Carbon Tetrachloride | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |