Pub. Date : 2017 Sep
PMID : 28628909
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP4F2 protein, a cytochrome P-450 isoform with proposed alpha-tocopherol omega-hydroxylase activity, decreased in HFD and even more in HFD+F mice liver; this finding was associated with increased hepatic levels of alpha-tocopherol and decreased formation of the corresponding long-chain metabolites alpha-13-hydroxy and alpha-13-carboxy chromanols. | alpha-Tocopherol | cytochrome P450 family 4 subfamily F member 2 | Homo sapiens |
| 2 | CYP4F2 protein, a cytochrome P-450 isoform with proposed alpha-tocopherol omega-hydroxylase activity, decreased in HFD and even more in HFD+F mice liver; this finding was associated with increased hepatic levels of alpha-tocopherol and decreased formation of the corresponding long-chain metabolites alpha-13-hydroxy and alpha-13-carboxy chromanols. | alpha-Tocopherol | cytochrome P450 family 4 subfamily F member 2 | Homo sapiens |
| 3 | A transient activation of CYP4F2 gene followed by a repression response was observed in HepG2 cells during the exposure to increasing levels of the lipogenic and cytotoxic agent palmitic acid; such gene repression effect was further exacerbated by the co-treatment with oleic acid and alpha-tocopherol and was also observed for PPAR-gamma and the SREBP isoforms 1 and 2. | alpha-Tocopherol | cytochrome P450 family 4 subfamily F member 2 | Homo sapiens |
| 4 | Such gene response was associated with increased uptake and omega-hydroxylation of alpha-tocopherol, which suggests a minor role of CYP4F2 in the enzymatic metabolism of vitamin E in HepG2 cells. | alpha-Tocopherol | cytochrome P450 family 4 subfamily F member 2 | Homo sapiens |