Title : Nonalcoholic fatty liver disease impairs the cytochrome P-450-dependent metabolism of α-tocopherol (vitamin E).

Pub. Date : 2017 Sep

PMID : 28628909






1 Functional Relationships(s)
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1 A transient activation of CYP4F2 gene followed by a repression response was observed in HepG2 cells during the exposure to increasing levels of the lipogenic and cytotoxic agent palmitic acid; such gene repression effect was further exacerbated by the co-treatment with oleic acid and alpha-tocopherol and was also observed for PPAR-gamma and the SREBP isoforms 1 and 2. Oleic Acid cytochrome P450 family 4 subfamily F member 2 Homo sapiens