Pub. Date : 2017 Aug
PMID : 28627705
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeting the PD-L1/DNMT1 axis in acquired resistance to sorafenib in human hepatocellular carcinoma. | Sorafenib | DNA methyltransferase 1 | Homo sapiens |
| 2 | Our data indicated that highly upregulated DNMT1 was positively correlated with PD-L1 overexpression in sorafenib-resistant HCC cells. | Sorafenib | DNA methyltransferase 1 | Homo sapiens |
| 3 | Moreover, inactivation of NFkappaB blocked PD-L1/STAT3/DNMT1 pathway in sorafenib-resistant HCC cells. | Sorafenib | DNA methyltransferase 1 | Homo sapiens |
| 4 | Functionally, genetic or pharmacological disruption of PD-L1 or/and DNMT1 sensitize HCC resistance to sorafenib. | Sorafenib | DNA methyltransferase 1 | Homo sapiens |
| 5 | Importantly, dual inactivation of PD-L1 and DNMT1 by their inhibitor synergistically disrupts the colony formation of sorafenib-resistant HCC cells. | Sorafenib | DNA methyltransferase 1 | Homo sapiens |
| 6 | These results demonstrate that targeting NFkappaB/PDL1/STAT3/DNMT1 axis is a new therapeutic strategy for preventing or overcoming the acquired resistance to sorafenib in HCC patients. | Sorafenib | DNA methyltransferase 1 | Homo sapiens |