Title : Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis.

Pub. Date : 2017 Jun 28

PMID : 28627172






2 Functional Relationships(s)
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1 The regiodivergent introduction of sugars at the C3, C5, and C11 positions of macrolactones was achieved by selecting appropriate chiral acids as catalysts or through introduction of stoichiometric boronic acid-based additives. Boronic Acids aldo-keto reductase family 1 member C4 Homo sapiens
2 Additionally, the C11 position of macrolactones was selectively functionalized through traceless protection of the C3/C5 diol with boronic acids prior to glycosylation. Boronic Acids aldo-keto reductase family 1 member C4 Homo sapiens