Title : Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone.

Pub. Date : 2017 Jun 1

PMID : 28626572






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The endogeneous hormone ANP signals via the natriuretic peptide receptor A (NPR-A) through raising intracellular cGMP concentrations, and is involved in blood pressure regulation and sodium homeostasis, as well as lipid metabolism and pancreatic function. Cyclic GMP natriuretic peptide receptor 1 Homo sapiens
2 The endogeneous hormone ANP signals via the natriuretic peptide receptor A (NPR-A) through raising intracellular cGMP concentrations, and is involved in blood pressure regulation and sodium homeostasis, as well as lipid metabolism and pancreatic function. Cyclic GMP natriuretic peptide receptor 1 Homo sapiens
3 The cis- and trans-isomers of one of our peptidomimetics, termed TOP271, exhibit a four-fold difference in NPR-A mediated cGMP synthesis in vitro. Cyclic GMP natriuretic peptide receptor 1 Homo sapiens