Pub. Date : 2017 Aug 1
PMID : 28625978
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | IDH1-mutant gliomas are dependent upon the canonical coenzyme NAD+ for survival. | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | We therefore hypothesized that a strategy combining NAD+ biosynthesis inhibitors with the alkylating chemotherapeutic agent temozolomide could potentiate NAD+ depletion-mediated cytotoxicity in mutant IDH1 cancer cells. | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | We therefore hypothesized that a strategy combining NAD+ biosynthesis inhibitors with the alkylating chemotherapeutic agent temozolomide could potentiate NAD+ depletion-mediated cytotoxicity in mutant IDH1 cancer cells. | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 4 | In IDH1-mutant-expressing cells, this consumption reduced further the abnormally lowered basal steady-state levels of NAD+, introducing a window of hypervulnerability to NAD+ biosynthesis inhibitors. | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 5 | In IDH1-mutant-expressing cells, this consumption reduced further the abnormally lowered basal steady-state levels of NAD+, introducing a window of hypervulnerability to NAD+ biosynthesis inhibitors. | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 6 | Thus, we find IDH1-mutant cancers have distinct metabolic stress responses to chemotherapy-induced DNA damage and that combination regimens targeting nonredundant NAD+ pathways yield potent anticancer efficacy in vivo Such targeting of convergent metabolic pathways in genetically selected cancers could minimize treatment toxicity and improve durability of response to therapy. | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |